A Unified Approach for Knowledge Modeling in Pharmaceutical Product Development
نویسندگان
چکیده
Development of a drug product is a complex, iterative process consisting of selection of a dosage form, excipients, processing route, operating equipment and so on. At each stage, knowledge in various forms, including heuristics, decision trees and mathematical models, is used in making decisions. Typically knowledge is modeled specifically for the tool that uses it, such as expert systems and mathematical modeling software. This makes it very difficult to share the knowledge across different tools and among development teams, and integrate various forms of knowledge to assist in making pharmaceutical product development decisions. To provide easier access to available knowledge and better decision support, we propose an open and unified approach to systematically model the different forms of knowledge.
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